Research
T and B cells are components of the immune system that are essential in fighting against infection-causing “foreign” pathogens, but are also involved in disease settings like cancer and autoimmunity where they can attack “self”. Our lab aims to understand the complex biology of T and B cells in the context of infection and cancer, by focusing on their phenotypic and functional profiles, antigen specificities and receptor repertoires. Our long-term goal is to develop rational and effective immune-based therapies to leverage on the immune system to fight cancer.
T cell repertoire analysis
We are interested in probing the repertoire of T cells in patients to study what they "see". By studying T cell specificities, we aim to uncover immunogenic and immunodominant antigens, and novel TCRs that may aid in the design of next generation immunotherapeautics such as vaccines and cellular therapy.
MHC / HLA
Antigens
T cell receptor
Tumor / Infected cell
T cell
Fundamental T cell biology
We are fascinated by T cells and their immense plasticity. Our aim is to uncover the molecular mechanisms that influence T cell development, differentiation and function using primary human samples and mouse models. By understanding the cell-intrinsic and -extrinsic factors that influence T cell biology, our goal is to modulate T cell function in various disease contexts.
naïve T cell
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Th1
Th2
Tcm
Tem
Trm
Tpex
Tex
Monoclonal antibody discovery
Monoclonal antibodies not only exert effector functions such as opsonisation, neutralisation and complement activation, but also facilitate our understanding of protein-protein biology. Our focus is to isolate and characterize monoclonal antibodies against actionable targets to understand how these different antibodies function in vivo.
B cell
Antibody
Targets
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